Endocrine Abstracts

Neutrophil gelatinase-associated lipocalin (NGAL) was shown to be highly useful in assessing kidney injury in patients with diabetic nephropathy. Taking into account recent data that dysthyroidism may have reversible effects on GFR the purpose of the study was to investigate potential relationship between serum NGAL levels, thyroid status and ultrasound thyroid characteristics in patients with type 1 diabetes (T1D) with CKD.Materials and methods: We recr...

Neutrophil gelatinase-associated lipocalin (NGAL) was shown to be highly useful in assessing kidney injury in patients with diabetic nephropathy. Taking into account recent data that dysthyroidism may have reversible effects on GFR the purpose of the study was to investigate potential relationship between serum NGAL levels, thyroid status and ultrasound thyroid characteristics in patients with type 1 diabetes (T1D) with CKD.Materials and methods: We recr...

Background: Diabetic nephropathy (DN) is a major cause of morbidity and mortality in type 1 diabetes (T1D) patients and associated with increased cardiovascular risk in type 2 diabetes (T2D) patients. Early detection of DN using neutrophil gelatinase-associated lipocalin (NGAL) assessment can help to reveal predisposed patients to its progression and to prevent progression of DN. Especially important it is in patients with normoalbuminuria.Aim: To determ...

Aims: Thyroid status disturbances are not rare among DKD patients. It is known that the genesis of anemia in DKD has a multifactorial nature, and the combination of DKD and anemia significantly impairs quality of life. In addition, anemia in diabetic patients with DKD occurs earlier and tends to be more severe compared with CKD patients without diabetes. The purpose of the study was to investigate potential relationship between thyroid status and iron metabolism profile in pat...

Aims: Thyroid function changes are common endocrine disturbance among patients with chronic kidney disease (CKD), including those receiving renal replacement therapy (RRT). The purpose of the study was to study the effect of RRT on thyroid function in patients with type 1 diabetes (T1D).Materials and methods: Thyroid hormone examination was performed before and after hemodialysis procedures (HD) in 9 patients with T1D (3 men and 6 women). Mean age was 41...

AimsDiabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD). Renal impairment may affect not only glycemic control, but also metabolism of biologically active cytokines such as adiponectin. Taking into account multiple effects of adiponectin the purpose of the study was to assess its changes in patients with type 1 diabetes (T1D) and comorbid CKD.Materials and methodsWe recruited 129 pati...

Introduction: The presence of diabetes-associated antibodies is an indicator of β-cell destruction. Our goal was to find out the prevalence of autoantibodies associated with the new onset of type 1 diabetes mellitus (DM1) without family history.Subjects and Methods: 22 patients (10 women and 12 men) with newly diagnosed DM1 no family history were examined. Average age of patients was 31.7±7.3 y.o., experience of DM1 was 2.3±0.8 months. All the...

The aim was to assess iodine status and thyroid structure changes in a cohort of patients with diabetes mellitus type 1 (DM1) at different stages of comorbid chronic kidney disease (CKD) after achievement of adequate iodine status in Belarus. We examined 62 patients (20m; 42f; age 42.1±12.07 years; BMI 26.14±5.27 kg/m2; duration of DM1 22.9±8.67 years; age at DM1 onset 19.89±12.72 years) at CKD stages 1, 2, 3, 5 (n=28; 21; 12; 1 respecti...

The aim was to analyze the efficiency of various methods of examination to update the degree of diabetic nephropathy and to determine the optimal to predict the decline in renal function in patients with diabetes mellitus type 1 (T1DM).We examined 50 patients (17 m; 33 f; age 40.1±11.7 years; BMI 25.9±5.0 kg/m2; duration of T1DM 22.3±8.1 years; and age at T1DM onset 21.6±13.2 years) at chronic kidney disease (CKD) stages 1,...

Introduction: Belarus is included into an iodine deficiency region of Central Europe. Therefore the National program widely was introduced from 1999. This program included salt iodization with KIO3, using of iodizated salt in the food industry and in the field of catering.The purpose of the research is iodine status monitoring in the Republic of Belarus from 1999 to 2012.The investigations included determination of the t...